Pheochromocytoma SlideShare

PHEOCHROMOCYTOMA Rare neuroendocrine tumor of the medulla of the adrenal glands 85-95% cases(originating in the chromaffin cells), or extra-adrenal chromaffin tissue that secretes excessive amounts of catecholomines (epinephrine and norepinephrine) -- hormones that regulate heart rate and blood pressure. Rare disorder. Equally common in women and men. Disease can occur at any age and rarely occurs after age 60 yrs. PHEOCHROMOCYTOMA A neuroendocrine tumor of the medulla of the adrenal glands (originating in the chromaffin cells) and secretes high amounts of catecholamines, mostly epinephrine, plus norepinephrine to a lesser extent. phaios dark chroma color kyto s cell -oma tumor. 3 Pheochromocytoma Javad ghahremani Medical student at shahid beheshti university 2. Introduction: Pheochromocytomas and paragangliomas are catecholamine- producing tumors derived from the sympathetic or parasympathetic nervous system. The diagnosis of pheochromocytomas provides a potentially correctable cause of hypertension, and their removal can prevent hypertensive crises that can be lethal

Pheochromocytoma 1. pheochromocytoma Kholoud Alharbi King Faisal University 2. Case B 36 year old woman is seen at the outpatient clinic because of intermittent high blood pressure. She complains about periodic sweating and panic attacks. there is intermittent tremor, palpitation and elevated blood pressure WHAT IS A PHEOCHROMOCYTOMA?Pheochromocytoma- Rare tumor of the adrenal gland tissue (chromaffin cells)Usually benign (non-cancerous)Malignant (canerous) can Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising Pheochromocytoma. 1. PHEOCHROMOCYTO MA Hamad Emad H. Dhuhayr. 2. CONTENTS • SOEPEL • PHEOCHROMOCYTOMA • REFFERENCES. 3. SOEPEL S A 35-year-old husband and father of three children, has been experiencing headaches and palpitations of increasing frequency and severity over the past six months. In addition, he has had periods of intense anxiety and. Slide 3 of 14 of Pheochromocytoma Pheochromocytoma - Pheochromocytoma Maria E. Ferris, MD, MPH Epidemiology Mean Age in children: 11 years Male 2:1 female Bilateral in 20% of cases 35 Malignant PATHOLOGY It is a tumor | PowerPoint PPT presentation | free to vie

A pheochromocytoma is a rare, catecholamine-secreting tumor derived from chromaffin cells. The term pheochromocytoma (in Greek, phios means dusky, chroma means color, and cytoma means tumor) refers.. Slide 2 of 67 of Pheochromocytoma and its anaesthetic managemen Neumann HPH, Young WF Jr, Eng C. Pheochromocytoma and paraganglioma. N Engl J Med. 2019 Aug 8;381(6):552-65. http://www.ncbi.nlm.nih.gov/pubmed/31390501?tool=bestpractice.com Symptoms are usually episodic and tend to progress as the tumor grows. The majority of these tumors are benign Presentation detailing the management of Pheochromocytoma

slide 17 of 60. Comments: Pheochromocytoma is a highly vascular tumor as can be seen here. Given the high degree of vascularization, selective arteriography was used for a number of years as a diagnostic tool when pheochromocytoma was suspected clinically You've unlocked unlimited downloads on SlideShare! Your download should start automatically, if not click here to downloa Slide 3: Pheochromocytomas get their name from their unique staining when exposed to chromium salts. They turn brown, as shown here in this image. Pheo meaning dark color and chroma from the chromium salts. Slide 4. Patients with pheochromocytoma can present with a variety of signs and symptoms Pheochromocytoma may also be referred to as adrenal paraganglioma. Distinct from paraganglioma / extra-adrenal pheochromocytoma, which arises from chromaffin cells of sympathetic ganglia. Distinct from composite pheochromocytoma, which are tumors composed of pheochromocytoma plus ganglioneuroma, ganglioneuroblastoma, neuroblastoma or peripheral. Slides: 19; Download presentation. Endocrine Physiology 4 The Adrenal Medulla, Pheochromocytoma Dr. Khalid Alregaiey . Adrenal Medulla • Medullary cells are derived from the embryonic neural crest, simply modified neurons (Chromaffin cells, also pheochromocytes). • Innervated by cholinergic preganglionic sympathetic neuron

Pheochromocytoma is a relatively rare tumor of the adrenal glands or of similarly specialized cells outside of the adrenal glands.; Headache, sweating, and a fast heartbeat are typical symptoms, usually in association with markedly high blood pressure.A pheochromocytoma secretes catecholamine hormones (adrenaline and related hormones) that are responsible for the characteristic symptoms Sporadic pheochromocytoma is usually diagnosed on the basis of symptoms or an incidental discovery on computed imaging, whereas syndromic pheochromocytoma is frequently diagnosed earlier in the course of disease because of biochemical surveillance or genetic testing. (See Pheochromocytoma in genetic disorders. Pheochromocytoma. Reviewer (s): Dharam Ramnani, MD. Home Endocrine Adrenal Pheochromocytoma. Pheochromocytoma. Pheochromocytoma. Pheochromocytoma : Chromaffin Reaction. Pheochromocytoma. Pheochromocytoma : Rule of 10s (the 10% tumor) Pheochromocytoma : Genetics pheochromocytoma Fatemeh Rahmani presence of a smaller piece. Slides: 30; Download presentation. Pheochromocytoma is a rare but extremely treacherous neuroendocrine tumor, usually occurring in the adrenals but sometimes elsewhere in the abdomen, pelvis, chest, neck, and head. It causes manifestations by secreting catecholamines into the circulation. Tragically, up to 50

A total of 68 procedures for pheochromocytoma were performed between June 1997 and February 2017. All patients were investigated and operated on using an established departmental protocol. Relevant data were retrieved from the hospital records of 533 patients who underwent 541 adrenalectomies for benign and malignant adrenal tumors in the same. Pheochromocytoma: An approach to diagnosis Best Pract Res Clin Endocrinol Metab. 2020 Mar;34(2):101346. doi: 10.1016/j.beem.2019.101346. Epub 2019 Oct 22. Authors Emilia Sbardella 1 , Ashley B Grossman 2 Affiliations 1 Department of Experimental Medicine, Sapienza University of Rome, Viale del Policlinico, 155, 00161, Rome, Italy. Electronic.

Pheochromocytoma may occur as a single tumor or as more than one growth. It usually develops in the center (medulla) of one or both adrenal glands. The adrenal glands are two triangle-shaped glands. One gland is located on top of each kidney. In rare cases, a pheochromocytoma occurs outside the adrenal gland slide 38 of 60. Comments: Pheochromocytoma (lower half of the image) surrounded by a thinned-out rim of adrenal cortex. The three zones of normal adrenal cortex are clearly seen here. The upper most layer just beneath the capsule consisting of small compact clusters of cells with hyperchromatic nuclei is zona glomerulosa - the site of. Axial, T2-weighted magnetic resonance imaging (MRI) scan showing large left suprarenal mass of high signal intensity on a T2-weighted image. Pulmonary manifestations of pheochromocytoma are infrequent and are not well documented. If remaining unrecognized or untreated, they can be a life-threatening condition. volume, vasodilation, increasing catalysis of glycogen See our User Agreement and.

  1. e synthesis, release, and metabolism in pheochromocytoma. Numbers in squares indicate sites of: 1) action of α- and β-adrenoceptor blockers or weight loss medications [phenter
  2. Pheochromocytoma 1. FUNCTIONS OF HORMONES SECRETED BY ADRENAL GLAND Adrenal medulla {Fight-or-flight response} Adrenaline (epinephrine) (Primarily) Boost the supply of oxygen and glucose to the brain and muscles (by increasing heart rate and stroke volume, vasodilation, increasing catalysis of glycogen in liver, breakdown of lipids in fat cells) Dilate the pupils Suppress non-emergency bodily.
  3. Adrenal Mass, Pheochromocytoma
  4. Pheochromocytoma and its anaesthetic managemen


  1. International Research Journal of Advanced Engineering and Science (IRJAES
  2. Pheochromocytoma • It is a tumour arising from chromaffin cells, from the adrenal medulla but can also arise from extraadrenal chromaffin tissues (Organ of Zuckerkandl). Recortar slides é uma maneira fácil de colecionar slides importantes para acessar mais tarde. Agora, personalize o nome do seu painel de recortes
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Pheochromocytoma - slideshare

Pheochromocytoma And Paraganglioma 756284 PPT. Presentation Summary : 6% of patients with pheochromocytoma and paraganglioma have it. It is usually mild; occasionally, it is severe. It predisposes to hemorrhoids, stercoral ulcers Home Endocrine Adrenal Pheochromocytoma Pheochromocytoma slide 19 of 60. Comments: The tumor cells in pheochromocytomas contain abundant finely granular cytoplasm which can be deeply basophilic or amphophilic. The granularity is due to the presence of membrane-bound,.

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Pheochromocytoma: Practice Essentials, Pathophysiology

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Malignant metastatic pheochromocytoma should be treated with alpha-blockers and beta-blockers. The tumor may be indolent and survival long-lasting. However, even with rapid tumor growth, blood pressure can be controlled. I-131 MIBG or more recently lutetium-177 dotatate can help relieve symptoms in patients with residual disease A pheochromocytoma also releases hormones, at much higher levels than usual. These extra hormones cause high blood pressure , which can damage your heart , brain , lungs , and kidneys Pheochromocytoma: State-of-the-Art and Future Prospects. Emmanuel L. Bravo, Emmanuel L. Bravo. 1 Department of Nephrology and Hypertension, Cleveland Clinic Foundation, Cleveland Ohio 44195. * Address all correspondence and requests for reprints to: Emmanuel L. Bravo, M.D., Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A51, Cleveland.

Pheochromocytoma and its anaesthetic managemen

Pediatric pheochromocytomaAdrenal gland diseases,Cushing syndrome,Addison disease

Comments: Pheochromocytomas frequently show atypical nuclear features, including striking hyperchromasia, giant nuclei, nuclear inclusions resulting from cytoplasmic invaginations, and bizarre forms.Many giant nuclei have smudged chromatin with a degenerative appearance. These changes are often distributed focally Slide 17 of 17 of Pheochromocytoma radiolog Pheochromocytoma and paraganglioma also occur in families without other associated clinical features, i.e., as isolated pheochromocytoma and paraganglioma, with susceptibility transmitted in an autosomal dominant fashion. Thus, an additional gene or genes is probably involved in isolated familial pheochromocytoma and paraganglioma Pheochromocytoma is estimated to occur in 2-8 of 1 million persons per year, and ∼0.1% of hypertensive patients harbor a pheochromocytoma. The mean age at diagnosis is ∼40 years, although the tumors can occur from early childhood until late in life Chemotherapy is the systemic therapy used for a pheochromocytoma or paraganglioma. Chemotherapy is the use of drugs to destroy tumor cells, usually by keeping the tumor cells from growing, dividing, and making more cells. People with a fast-growing, metastatic pheochromocytoma or paraganglioma may be treated with chemotherapy

Symptoms. Phaeochromocytomas may present with a classic symptom triad of headache, palpitations, and sweating. Hypertension is present in around 90% of cases, although it is paroxysmal in 35-50% of these. Other non-specific presentations include anxiety, lethargy, nausea, weight loss, hyperglycaemia, and tremor Pheochromocytoma tissue Slides (Diseased). Novus Control Slides contain a single tissue section mounted on a glass slide. Backed by our 100% Guarantee The primary treatment for a pheochromocytoma is surgery to remove the tumor. Before you have surgery, your doctor will likely prescribe specific blood pressure medications that block the actions of the high-adrenaline hormones to lower the risk of developing dangerously high blood pressure during surgery

Pheochromocytoma - Symptoms, diagnosis and treatment BMJ

PHEOCHROMOCYTOMA, a catecholamine-producing tumor arising in the adrenal medulla, has an estimated incidence of two to eight cases per million persons annually (1, 2).Its clinical hallmark is sustained or intermittent hypertension often associated with paroxysmal symptoms ().Pheochromocytoma should also be considered if a patient has labile hypertension, hypertension resistant to. Tienes dos glándulas suprarrenales, una encima de cada riñón. Normalmente, el feocromocitoma se desarrolla en una sola glándula suprarrenal. Pero los tumores pueden desarrollarse en ambos. Si tienes un feocromocitoma, el tumor libera hormonas que pueden causar presión arterial alta, dolor de cabeza, sudoración y síntomas de un ataque de. Open in new tab Download slide William F. Young: Catecholamine-secreting tumors are rare, with an annual incidence of 2-8 cases per million people. Based on screening studies for secondary causes of hypertension in outpatients, the prevalence of PCC has been estimated at 0.1% to 0.6%


Pheochromocytoma management - SlideShar

The 2004 WHO classification of endocrine tumors defines pheochromocytoma as a tumor arising from chromaffin cells in the adrenal medulla. Closely related tumors in extra-adrenal sympathetic and parasympathetic paraganglia are classified as extra-adrenal paragangliomas. A pheochromocytoma is an intra Pheochromocytoma Definition Pheochromocytoma is a tumor of special cells (called chromaffin cells), most often found in the middle of the adrenal gland [1]. Description Because pheochromocytomas arise from chromaffin cells, they are occasionally called chromaffin tumors Pheochromocytoma tissue was fixed for 3 h in 2% formaldehyde and 2% glutaraldehyde in 0.1 mol/L phosphate buffer, pH 7.3. Tissue slices were postfixed for 90 min (2% OsO 4 in 0.1 mol/L cacodylate buffer, pH 7.3), dehydrated in ethanol, and embedded in epoxy resin. Ultrathin sections were stained with uranyl acetate and lead citrate and examined. Context: Diagnosis of pheochromocytoma depends on biochemical evidence of catecholamine production by the tumor. However, the best test to establish the diagnosis has not been determined. Objective: To determine the biochemical test or combination of tests that provides the best method for diagnosis of pheochromocytoma. Design, setting, and participants: Multicenter cohort study of patients. Pheochromocytoma versus adrenal cortical carcinoma. Pheochromocytoma and adrenal cortical carcinoma overlap histologically. Favour pheochromocytoma: Small chickenwire-pattern blood vessels, nests, salt-and-pepper chromatin, red blood cell extravasation. Favour adrenal cortical carcinoma: Nucleolus, sheeting. Malignant pheochromoctyom

Pheochromocytoma is a tumor that originates from either chromaffincells in adrenal medulla or in other paraganglia tissues of the sympathetic nervous system. The periope-rative management is quite challenging especially in view of hemodynamic fluctuations. Pheochromocytoma is challenging in view of the impact of excessive an Slide 1 Adrenal Disease Jennii Stephens, PA-C Slide 2 Diseases of the Adrenal Gland Anatomy and Physiology Decreased adrenal function Cortex Cortex Addisons DiseaseAddison Pheochromocytoma là gì • Phaeochromocytomas(PHEOs) là những khối u nội tiết- thần kinh tiết ra các catecholamine, có nguồn gốc từ những tế bào ưa crom của tủy thượng thận hoặc các hạch giao cảm Slide 1 Author: phong Created Date Corticosteroids precipitating pheochromocytoma crisis. Although our patient appears to be the first reported case of a hemorrhagic pheochromocytoma temporally associated with corticosteroid therapy, previously published case reports have described pheochromocytoma presenting after steroid administration. In 1970 Cowley et al Most were located in the adrenal glands, and extra-adrenal composite pheochromocytoma is extremely rare. Only 4 cases in the retroperitoneum have been described in the online database PUBMED. Here, we report a case of retroperitoneal extra-adrenal composite pheochromocytoma and review the related literature

WebPathology is a free educational resource with 11159 high quality pathology images of benign and malignant neoplasms and related entities Pheochromocytoma crisis is a hypertensive emergency that affects one or more organ systems, such as the brain, heart, kidney, and aorta. Although the goal of treatment for pheochromocytoma crisis is to remove the tumor, preoperative treatment to reduce perioperative risk must be undertaken

Pheochromocytoma - WebPatholog

Although GATA3 has been recognized as a useful marker for mammary and urothelial carcinomas, there is large variation in GATA3 expression detected in pheochromocytoma (PC) and paraganglioma (PGL), from 90% to less than 5%. For GATA3 to be a useful diagnostic marker for PCCs/PGLs, the reasons for suc weebly slideshare, harsh mohan pathology 1 / 11. quick review and mcqs pdf free, pathology practice examination slideshare, oral pathology test series neet dental pg practice mcqs, pathology mcq, autonomic nervous system mcqs medical mcqs, pathology cardiovascular system a obesity Próxima SlideShare. Cargando en Pheochromocytoma • It is a tumour arising from chromaffin cells, from the adrenal medulla but can also arise from extraadrenal chromaffin tissues (Organ of Zuckerkandl). • It is catecholamine secreting tumours • Pheochromocytomas were first identified by Frankel in 1885, but were not named as such.

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Pheochromocytoma it's a complex entity and could be silent in until 30% of the cases, should be suspected in all neuroendocrine retroperitoneal tumors. Virtual slides The virtual slide(s) for. Pheochromocytoma produce an excess amount of catecholamine hormone, which include norepinephrine (noradrenaline), epinephrine (adrenaline), and dopamine. The release of catecholamines can cause persistent or episodic high blood pressure, headache, sweating and other symptoms Pheochromocytoma, a rare disease occurring more often in adults than in children, accounts for only about 1% of pediatric hypertension and often is associated with a variety of genetic syndromes. The National Registry of Childhood Cancers reports an incidence of 0.11 benign and 0.02 malignant pheochromocytomas per 1 million children Pheochromocytoma (PHEO or PCC) is a rare tumor of the adrenal medulla composed of chromaffin cells, also known as pheochromocytes. When a tumor composed of the same cells as a pheochromocytoma develops outside the adrenal gland, it is referred to as a paraganglioma. These neuroendocrine tumors are capable of producing and releasing massive amounts of catecholamines, metanephrines, or.

Anaesthetic management of pheochromocytomaAdrenergic bockers (VK)Antiadrenergic drugs - drdhritiNcp

Surgery for Pheochromocytoma. The Best Surgical Options for Removal of Pheochromocytomas. There are 4 primary radiological (x-ray) tests to examine the adrenal glands (and the rest of the abdomen) for the presence of a tumor (the word tumor simply means mass; these can be benign or malignant) Patricia L. M. Dahia gives an overview of insights learned from the study of pheochromocytomas and paragangliomas, which carry the highest degree of heritability of all human tumours —The World Health Organization reserves the term pheochromocytoma for tumors arising from chromaffin cells in the adrenal medulla. Closely related tumors in extra-adrenal sympathetic and parasympathetic paraganglia are classified as extra-adrenal paragangliomas. A pheochromocytoma is an intra-adrenal sympathetic paraganglioma A pheochromocytoma is a tumor of the interior portion, or medulla, of the adrenal glands that can release high levels of epinephrine and norepinephrine. A pheochromocytoma can also be located elsewhere in the body in similar specialized tissue. In this case, they are referred to as extra-adrenal pheochromocytomas or paragangliomas Introduction. Pheochromocytoma is a rare neuroendocrine tumour that produces and stores adrenaline and noradrenaline.1, 2 It usually presents with symptoms related to catecholamines excess, including palpitations, paroxysmal or sustained hypertension, headache, anxiety, fatigue. The severity of these symptoms is extremely variable and depends on the genetics of the tumour itself.3.